胎児診断の権威:夫律子(Dr.ぷぅ)のすべて

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クリフム CRIFM のメンバーに代わりましてすべてのママ、パパ、そしてクリフムワールドに興味をお持ちの方がたにご挨拶させていただきます。
クリフムは2006年6月に、胎児医学を専門といたしました胎児診断専門施設として香川県に開設いたしました。全国の多くの患者様の期待に答えて、2007年に大阪に移転し、2020年には胎児脳を詳しく診断するための別フロアを開設。胎児診断を主とするフロアと、胎児脳専用フロアの二段構造となりました。これもひとえに皆様方の熱いご支援と力強いご協力の賜物と、心より感謝申し上げます。

夫院長

Dr.ぷぅのプロフィール
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夫 律子(ぷぅ りつこ)
(医学博士、日本産科婦人科学会認定 産婦人科専門医、日本超音波医学会認定 超音波専門医、日本人類遺伝学会認定 臨床遺伝専門医、法学士、理学修士、経営学修士)
Ritsuko Kimata Pooh, MD, PhD, LLB, MSc, MBA.

経歴

  • 兵庫県出身
  • 兵庫県立神戸高等学校 卒業
  • 慶応義塾大学法学部法律学科 卒業
  • 徳島大学医学部医学科 卒業
  • Chinese University Hong Kong 大学院修士 卒業
  • 経営学修士(MBA) Globis経営大学院大学 卒業

専門分野

  • 胎児脳診断
  • 周産期医学
  • 出生前診断
  • 胎児超音波医学(超音波発生学・超音波遺伝学)
  • 胎児神経医学

資格

  • 法学士(慶應義塾大学)
  • 医学博士(徳島大学)
  • 理学修士(Chinese University Hong Kong)
  • 経営学修士(Globis経営大学院大学)
  • 日本産科婦人科学会認定 産婦人科専門医
  • 日本超音波医学会認定 超音波専門医
  • 日本超音波医学会認定 超音波指導医
  • 日本人類遺伝学会・日本遺伝カウンセリング学会認定 臨床遺伝専門医
  • 大阪府医師会 母体保護法指定医
  • -妊娠初期超音波資格- FMF(イギリス)認定
  • NT certificate (NT資格)
  • NB certificate (鼻骨資格)
  • TR certificate (三尖弁逆流資格)
  • DV certificate (静脈管血流資格)
  • UA certificate (子宮動脈血流資格)
  • NIDA Clinical Trials Network Good Clinical Practice

現職

  • クリフム出生前診断クリニック 院長
  • Wayne州立大学(米国) 産婦人科 特命客員教授
  • Pirogovロシア国立研究医科大学 名誉教授
  • 国際Dubrovnik大学 Human Science (クロアチア) 教授
  • 順天堂大学医学部産婦人科学講座 客員教授
  • 大阪大学大学院医学系研究科 招へい教授
  • 聖マリアンナ医科大学産婦人科学講座 客員教授
  • 国際周産期医学アカデミー 副会長
  • 国際イアンドナルド超音波講座 国際選任理事、日本支部長

所属学会・役員など

  • International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) /ISUOG Trustee
  • International Society of Ultrasound in Obstetrics and Gynecology (ISUOG) /Ambassador to Asia
  • International Academy of Perinatal Medicine /副会長
  • The Society of “The Fetus as a Patient” 国際胎児病学会 /国際理事
  • World Association of Perinatal Medicine 世界周産期学会 /Educational Committee Board
  • Fetal Medicine foundation Asia Pacific (FMF APAC) /Honorary Treasurer
  • Ian Donald Inter-University School of Medical Ultrasound /国際選任理事・アジア支部長
  • Global Congress of Maternal and Infant Health /国際教育委員
  • 日本母体胎児医学会/特任理事
  • 日本産婦人科超音波研究会 (JSUOG) /副理事長
  • 日本産科婦人科遺伝診療学会/代議員
  • 日本妊娠高血圧学会/代議員
  • 日本人類遺伝学会/評議員
  • 日本遺伝カウンセリング学会/評議員
  • 日本産婦人科・新生児血液学会/評議員
  • 日本小児神経学会/評議員
  • 臨床細胞分子遺伝研究会/評議員
  • 日本イアンドナルド超音波講座/代表
  • 中国・四国出生前医学研究会/世話人
  • 関西出生前診療研究会/世話人
  • 新胎児学研究会/世話人
  • 胎児MRI研究会/世話人
  • 日本産科婦人科学会/会員
  • 日本超音波医学会/会員
  • Asian and Oceanian Child Neurology Association/終身会員
  • Journal of Perinatal Medicine(ISSN:0300-5577)/編集委員
  • The Taiwan Journal of Obstetrics and Gynecology(ISSN:1028-4559)/編集委員
  • Ginekologia Polska (Polish Journal of Gynecology)(ISSN:00170011)/編集顧問委員
  • Perinatal Journal(ISSN:1303-3124)/編集委員
  • Case Reports in Perinatal Medicine (ISSN: 2192-8959)/編集委員
  • American Journal of Pediatrics(ISSN Print:2472-0887 ISSN Online: 2472-0909)/編集委員
  • Human Genetics & Embryology(ISSN:2161-0436)/編集委員

賞罰

  • Alfred Kratochwil 賞 (第21回 世界産婦人科超音波学会, 21st ISUOG, 2011)
  • International Academy of Perinatal Medicine (国際周産期医学アカデミー) 正会員受賞 (2012.12)
  • Lifetime achievement 賞 (第12回世界周産期医学会12nd WCPM, 2015.11)
  • Sir William Liley 賞(第32回国際Fetus as a Patient, 2016.5)
  • Short Oral Presentation Award (第26回世界産婦人科超音波学会, 26th ISUOG, 2016, Rome)
  • -Clinical significance of 3D HDlive silhouette/flow in neurosonoembryology and fetal neurosonography- “Magnificent achievements in the visualization of early human development” Award(第14回 世界周産期医学会, 14th WCPM, 2019, Istanbul)

執筆論文一覧

Published Books

  1. Donald School Atlas of Fetal Anomalies Kurjak A, Pooh RK, Chervenak FA Jaypee Brothers Medical Publishers, India, 2023
  2. Donald School Atlas of Advanced Ultrasound in Obstetrics and Gynecology Pooh RK, Kurjak A Jaypee Brothers Medical Publishers, India, 2015
  3. Donald School Textbook of PowerPoint Presentation on Advanced Ultrasound in Obstetrics & Gynecology Wataganara T, Pooh RK, Kurjak A Jaypee Brothers Medical Publishers, India, 2015
  4. Fetal Neurology Pooh RK, Kurjak A Jaypee Brothers Medical Publishers, India, 2009
  5. An Atlas of Fetal Central Nervous System Disease Diagnosis and Management Pooh RK, Maeda K, Pooh KH Parthenon/CRC Press, London, New York, 2003

Original Articles

  1. Early diagnosis of fetal ganglionic eminence cysts: imaging, outcome and genetic associations, revealing role of mitochondrial dysfunction Birnbaum R, Malinger G, Miremberg H, Brusilov M, Pooh RK, Rybak-Krzyszkowska M, Viñals F, Vo TS, Gupta R, Gupta S, Dimri N, Ochoa JH, Weissbach T, Lanzarone V, Quinton A, Levy M, Kidron D, Haratz KK Ultrasound Obstet Gynecol. 2026. PMID: 41674274 DOI: 10.1002/uog.70180
  2. Normal values and distribution of ventricular global longitudinal strain in 513 healthy fetuses measured by two-dimensional speckle-tracking echocardiography: a multi-institutional cohort study Akazawa Y, Yasukochi S, Takei K, Pooh RK, et al. Heart Vessels. 2025;40:414-425. PMID: 39476252 DOI: 10.1007/s00380-024-02477-4
  3. Transvaginal ultrasound assessment of corpus callosal length in the fetus: multicenter cross-sectional study Paladini D, Parodi S, Xie H, Viñals F, Haratz K, Birnbaum R, Azumendi G, Pomar L, Montaguti E, Acharya P, Volpe P, Cruz MP, Katrin K, Chaoui R, Pooh R, et al. Ultrasound Obstet Gynecol. 2025. PMID: 40321147 DOI: 10.1002/uog.29227
  4. Aspirin delays preterm birth in pregnancies at high risk for preterm pre-eclampsia: evidence from randomized clinical trial in Asia Leung HHY, Papastefanou I, Chen Y, Nguyen-Hoang L, Nguyen DA, Dinh LT, Pooh RK, Shiozaki A, Zheng M, Hu Y, Wu Y, et al., Poon LC Ultrasound Obstet Gynecol. 2025;66:24-32. PMID: 40454801 DOI: 10.1002/uog.29255
  5. Impact of Aspirin on Timing of Birth in Pregnancies With Clinical Manifestations of Placental Dysfunction: Evidence From a Multicentre Randomised Clinical Trial Papastefanou I, Chen Y, Nguyen-Hoang L, Nguyen DA, Dinh LT, Pooh RK, Shiozaki A, Zheng M, et al., Poon LC BJOG. 2025;132:1460-1468. PMID: 40364747 DOI: 10.1111/1471-0528.18211
  6. The fetal brain neurosonography in trisomy 21: the seagull sign and thinned subplate Pooh RK, Machida M, Uenishi K, Barreto EQS, Wah IYM, Poon LC, Itoh K, Nakamura T, Chiyo H, Ohashi H, Takeda M, Shimokawa O, Matsubara Y Am J Obstet Gynecol. 2025; Volume 233, Issue 4: 315.e1-315.e20. DOI: 10.1016/j.ajog.2025.04.054
  7. Prenatal Diagnosis of Fetal Brain Asymmetry with Normal Amniotic Fluid Genetic Testing: A Somatic Variant in the Brain Pooh RK, Itoh K, Endo M, Fukuda H, Takeda M, Shimokawa M, Matsubara Y Am J Obstet Gynecol. 2025. DOI: 10.1016/j.ajog.2025.07.037
  8. Prenatal evaluation, diagnosis and management of fetal corpus callosal abnormalities: international Delphi consensus Corroenne R, Paladini D, Papastefanou I, Chaoui R, Pomar L, Guibaud L, Krajden Haratz K, Pooh RK, Herrera M, Ximenes R, Azumendi G, Pilu G, Salomon LJ, and Collaborators Ultrasound Obstet Gynecol. 2025. PMID: 40847729 DOI: 10.1002/uog.70003
  9. Validation of the first-trimester machine learning model for predicting pre-eclampsia in an Asian population NH Long, Sahota D, RK Pooh, D Honglei, C Noppadol, A Sekizawa, SW Shaw, S Seshadri, M Choolani, P Yapan, WS Sim, R Ma, WC Leung, SL Lau, NM Wing Lee, HY Hillary Leung, T Meshali, H Meiri, Y Louzoun, LC Poon Int J Gynecol Obstet. 2024; 00: 1-10. DOI: 10.1002/ijgo.15563
  10. Implementation of first-trimester screening and prevention of preeclampsia: a stepped wedge cluster-randomised trial in Asia L Nguyen-Hoang, LT Dinh, AST Tai, DA Nguyen, RK Pooh, A Shiozaki, M Zheng, YHR Ma, A Kusuma, P Yapan, A Gosavi, M Kaneko, S Luewan, TY Chang, N Chaiyasit, T Nanthakomon, H Liu, SW Shaw, WC Leung, ZA Mahdy, A Aguilar, HHY Leung, NMW Lee, SL Lau, IYM Wah, X Lu, DS Sahota, MKC Chong, LC Poon CirculationVolume 150, Issue 16, 15 October. 2024; Pages 1223-1235. PMID: 38923439 DOI: 10.1161/CIRCULATIONAHA.124.069907
  11. Change in client choice under multiple prenatal genetic testing options including noninvasive prenatal testing (NIPT) after genetic counseling in a Japanese maternity hospital Naruse K, Pooh RK, Kyukawa Y, Tsunemi T, Yamada T J Obstet Gynaecol Res. 2023 Sep;49(9):2337-2342. PMID: 37424195 DOI: 10.1111/jog.15740
  12. Change in client choice under multiple prenatal genetic testing options including noninvasive prenatal testing (NIPT) after genetic counseling in a Japanese maternity hospital Naruse K, Pooh RK, Kyukawa Y, Tsunemi T, Yamada T J Obstet Gynaecol Res. 2023. PMID: 37424195 DOI: 10.1111/jog.15740
  13. Evaluation of screening performance of first-trimester competing-risks prediction model for small-for-gestational age in Asian population Nguyen-Hoang L, Papastefanou I, Sahota DS, Pooh RK, Zheng M, Chaiyasit N, Tokunaka M, Shaw SW, Seshadri S, Choolani M, Yapan P, Sim WS, Poon LC Ultrasound Obstet Gynecol. 2023 July;. PMID: 37552550 DOI: 10.1002/uog.27447
  14. Cat-Ear-Line: A Sonographic Sign of Cortical Development? Matsuzawa N, Poon LC, Machida M, Nakamura T, Uenishi K, Wah YM, Moungmaithong S, Itakura A, Chiyo H, Pooh RK J Ultrasound Med. 2022; 9999:1–13. PMID: 36534508
  15. D-karyo—A New Prenatal Rapid Screening Test Detecting Submicroscopic CNVs and Mosaicism Shimokawa O, Takeda M, Ohashi H, Shono-Ota A, Kumagai M, Matsushika R, Masuda C, Uenishi K, Kimata Pooh RK Diagnostics. 2021; 11(2):337. PMID: 33670620 DOI: 10.3390/diagnostics11020337
  16. Fetal Megalencephaly with Cortical Dysplasia at 18 Gestational Weeks Related to Paternal UPD Mosaicism with PTEN Mutation Pooh RK, Machida M, Imoto I, Arai EN, Ohashi H, Takeda M, Shimokawa O, Fukuta K, Shiozaki A, Saito S, Chiyo H Genes. 2021; 12(3):358. PMID: 33801456 DOI: 10.3390/genes12030358
  17. Placental Types and Effective Perinatal Management of Vasa Previa: Lessons from 55 Cases in a Single Institution Tachibana D, Misugi T, Pooh RK, Kitada K, Kurihara Y, Tahara M, Hamuro A, Nakano A, Koyama M Diagnostics. 2021; 11(8):1369. PMID: 34441302 DOI: 10.3390/diagnostics11081369
  18. Clinical Validation of Fetal cfDNA Analysis Using Rolling-Circle-Replication and Imaging Technology in Osaka (CRITO Study) Pooh RK, Masuda C, Matsushika R, Machida M, Nakamura T, Takeda M, Ohashi H, Kumagai M, Uenishi K, Roos F, Persson F, Shimokawa O Diagnostics. 2021; 11(10):1837. PMID: 34679535
  19. Diagnosis of fetal tachyarrhythmia at 12weeks' gestation using spatiotemporal image correlation Inamura N, Pooh RK Ultrasound Obstet Gynecol. 2020 Feb;55(2):282-283. PMID: 31081557 DOI: 10.1002/uog.20345
  20. Early Sonographic Findings for Suspecting de novo Single-gene Mutation Pooh RK, Machida M, Nakamura T,Matsuzawa N,Chiyo H Donald School Journal of Ultrasound in Obstetrics and Gynecology, Volume 14 Issue 2 (April–June. 2020) 125-130. DOI: 10.5005/jp-journals-10009-1643
  21. Increased Sylvian fissure angle as early sonographic sign of malformation of cortical development Pooh RK, Machida M, Nakamura T, Uenishi K, Chiyo H, Itoh K, Yoshimatsu J, Ueda H, Ogo K, Chaemsaithong P, Poon LC Ultrasound Obstet Gynecol. 2019 Aug;54(2):199-206. PMID: 30381845 DOI: 10.1002/uog.20171
  22. Transvaginal three-dimensional assessment of Sylvian fissures at 18-30 weeks' gestation Poon LC, Sahota D, Chaemsaithong P, Nakamura T, Machida M, Naruse K, Wah IYM, Leung TY, Pooh RK Ultrasound Obstet Gynecol. 2019 Aug;54(2):190-198. PMID: 30381851 DOI: 10.1002/uog.20172
  23. HDlive Flow Silhouette Mode for Diagnosis of Ectopia Cordis With a Left Ventricular Diverticulum at 15 Weeks' Gestation Hata T, Ito M, Nitta E, Pooh RK, Sasahara J, Inamura N J Ultrasound Med. 2018 Oct;37(10):2465-2467. PMID: 29528126 DOI: 10.1002/jum.14583
  24. Generation of Induced Pluripotent Stem Cells and Neural Stem/Progenitor Cells from Newborns with Spina Bifida Aperta Bamba Y, Nonaka M, Sasaki N, Shofuda T, Kanematsu D, Suemizu H, Higuchi Y, Pooh RK, Kanemura Y, Okano H, Yamasaki M Asian Spine J. 2017 Dec;11(6):870-879. PMID: 29279741 DOI: 10.4184/asj.2017.11.6.870
  25. Three-dimensional neurosonography - a novel field in fetal medicine Lipa M, Pooh RK, Wielgoś M Ginekologia Polska,. 2017;88(4):215-221. PMID: 28509324 DOI: 10.5603/GP.a2017.0041
  26. Basic Neuroimaging Tips and Tricks Pooh RK Ultrasound in Obstetrics & Gynecology New Advances Presentations Book, 2017, pp107-112.
  27. HDlive Silhouette and HDlive Flow - What is Added to Prenatal Diagnosis? Pooh RK Ultrasound in Obstetrics & Gynecology New Advances Presentations Book, 2017, pp113-118. DOI: 10.5005/jp-journals-10009-1447
  28. Abstracts of the 26th World Congress on Ultrasound in Obstetrics and Gynecology, Rome, Italy, 24-28 September 2016 Pooh RK Ultrasound Obstet Gynecol. 2016 Sep;48 Suppl 1:54. PMID: 26959534 DOI: 10.1002/uog.16166
  29. EP05.10: Doppler assessment of hypertrophic cardiomyopathy in a case of Costello syndrome Kurihara Y, Tachibana D, Uemura R, Yokoi NW, Pooh RK, Kenji F, Kawauchi Y, Mika S, Suzuki T, Murakami Y, Yaoita M, Aoki Y, Koyama M Ultrasound Obstet Gynecol. 2016 Sep;48 Suppl 1:286-287. DOI: 10.1002/uog.16856
  30. Prenatal findings of hypertrophic cardiomyopathy in a severe case of Costello syndrome Uemura R, Tachibana D, Kurihara Y, Pooh RK, Aoki Y, Koyama M Ultrasound Obstet Gynecol. 2016 Dec. PMID: 26916728 DOI: 10.1002/uog.15888
  31. Three-dimensional HDlive Thick-Slice Silhouette of Fetal Brain Pooh RK Donald School Journal of Ultrasound in Obstetrics and Gynecology, January-March. 2016; 10(1): 1-2. DOI: 10.5005/jp-journals-10009-1435
  32. Novel Application of HDlive Silhouette and HDlive Flow Clinical Significance of the ‘See-through Fashion in Prenatal Diagnosis Pooh RK Donald School Journal of Ultrasound in Obstetrics and Gynecology, January-March. 2016; 10(1): 90-98. DOI: 10.5005/jp-journals-10009-2064
  33. Fetal Neuroimaging of Neuronal Migration Disorder by Ultrasound. J. Kyoto Pref. Univ Pooh RK Med. 2016; 125(4), 233-240. DOI: 10.1017/s0965539508002106
  34. Prenatal Diagnosis of Low-set Ears with Asymmetrical Microtia in the First Trimester Pooh RK Donald School Journal of Ultrasound in Obstetrics and Gynecology, January-March. 2016; 10(1): 111-112. DOI: 10.5005/jp-journals-10009-1451
  35. Recent Advances in 3D Ultrasound, Silhouette Ultrasound, and Sonoangiogram in Fetal Neurology Pooh RK Donald School Journal of Ultrasound in Obstetrics and Gynecology, April-June. 2016; 10(2): 193-200.
  36. Fetal magnetic resonance imaging and ultrasound Wataganara T, Ebrashy A, Aliyu LD, Moreira de Sa RA, Pooh RK, Kurjak A, Sen C, Adra A, Stanojevic M Journal of Perinatal Medicine. 2016; 44(5): 533-42.
  37. In vitro characterization of neurite extension using induced pluripotent stem cells derived from lissencephaly patients with TUBA1A missense mutations Bamba Y, Shofuda T, Kato M, Pooh RK, Tateishi Y, Takanashi J, Utsunomiya H, Sumida M, Kanematsu D, Suemizu H, Higuchi Y, Akamatsu W, Gallagher D, Miller FD, Yamasaki M, Kanemura Y, Okano H Molecular Brain July. 2016; 9(1): 70-83. PMID: 27431206 DOI: 10.1186/s13041-016-0246-y
  38. Three-dimensional Ultrasound in Detection of Fetal Anomalies Pooh RK, Kurjak A Donald School Journal of Ultrasound in Obstetrics and Gynecology, July-September. 2016;10(3): 214-234. DOI: 10.5005/jp-journals-10009-1471
  39. Ultrasound in Africa: what can really be done? Aliyu LD, Kurjak A, Wataganara T, de Sá RA, Pooh RK, Sen C, Ebrashy A, Adra A, Stanojevic M Journal of Perinatal Medicine, 2015 Sep; Epub ahead of print. PMID: 26389632
  40. 3D/4D sonography – any safety problem Pooh RK, Maeda K, Kurjak A, Sen C, Ebrashy A, Adra A, Dayyabu AL, Wataganara T, de Sá RA, Stanojevic M Journal of Perinatal Medicine,. 2015 Sep; [ ]. PMID: 26376219
  41. A New Field of 'Fetal Sono-ophthalmology' by 3D HDlive Silhouette and Flow Pooh RK Donald School Journal of Ultrasound in Obstetrics and Gynecology, July-September 2015; 9(3): pp221-222.
  42. Controversial ultrasound findings in mid trimester pregnancy Ebrashy A, Kurjak A, Adra A, Aliyu LD, Wataganara T, Moreira de Sá RA, Pooh RK, Sen C, Stanojevic M Evidence based approach.Journal of Perinatal Medicine, October. 2015 Oct; [ ]. PMID: 26506099
  43. Novel application of three-dimensional HDlive imaging in prenatal diagnosis from the first trimester Pooh RK, Kurjak A Journal of Perinatal Medicine. 2015 Mar; 43(2): pp147-58 PMID: 25014518
  44. 'See-through Fashion' in Prenatal Diagnostic Imaging Pooh RK Donald School Journal of Ultrasound in Obstetrics and Gynecology, April-June 2015; 9(2): pp111 DOI: 10.5005/jp-journals-10009-1397
  45. Diagnosis of a case of Dandy-Walker malformation aided by measurement of the brainstem-vermis angle at 14 weeks gestation Ichizuka Kiyotake, Mishina Miyuki, Hasegawa Junichi, Matsuoka Ryu, Sekizawa Akihiko, Pooh Ritsuko K Journal of Obstetrics and Gynaecology Research 2015 May; 41(5): pp790-793 PMID: 25490874
  46. 13-week Pulmonary Sonoangiogram by 3D HDlive Flow Pooh RK Donald School Journal of Ultrasound in Obstetrics and Gynecology, October-December 2015;9(4): pp355-35 DOI: 10.5005/jp-journals-10009-1421
  47. Whole exome sequencing revealed biallelic IFT122 mutations in a family with CED1 and recurrent pregnancy loss Y. Tsurusaki, R. Yonezawa, M. Furuya, G. Nishimura, R.K. Pooh, M. Nakashima, H. Saitsu, N. Miyake, S. Saito, N. Matsumoto Clin Genet. 2014 Jun;85(6):592-594.
  48. Recurrent structural malformations identified among Mowat–Wilson syndrome fetuses Yan Zhou, Jin Huang, Yvonne Kwun Yue Cheng, Tak Yeung Leung, Ritsuko K. Pooh, Fai Man Lo, Kwong Wai Choy Prenatal Diagnosis, 2014 Mar; 34(3): pp296-298 PMID: 24375696
  49. Hypoplasia of the spinal cord in a case of foetal akinesia/arthrogryposis sequences Itoh K, Pooh R, Kanemura Y, Yamasaki M, Fushiki S Neuropathol Appl Neurobiol. 2013 Jun; 39(4): pp441-444 PMID: 23421748
  50. Brain Malformation with loss of normal FGFR3 expression in thanatophoric dysplasia type I Kyoko Itoh, Ritsuko K. Pooh, Yonehiro Kanemura, Mami Yamasaki, Shinji Fushiki Neuropathology 2013 Dec; 33(6): pp663-666 PMID: 23551494
  51. Noninvasive Prenatal Diagnosis of Common Fetal Chromosomal Aneuploidies by Maternal Plasma DNA Sequencing Tze Kin Lau, Fang Chen, Xiaoyu Pan, Ritsuko K Pooh, Fuman Jiang, Yihan Li, Hui Jiang, Xuchao Li, Shengpei Chen, Xiuqing Zhang J Matern Fetal Neonatal Med. 2012 Aug;25(8):1370-4.
  52. First trimester serum markers stability during sample transportation from the obstetrical site to the screening laboratory Sahota DS, Pooh RK, Choy KW, Leung TY, Lau TK J Matern Fetal Neonatal Med. 2012 Jul;25(7):966-9. PMID: 21740321
  53. 3D/4D sonography moved prenatal diagnosis of fetal anomalies from the second to the first trimester of pregnancy Pooh RK, Kurjak A J Matern Fetal Neonatal Med. 2012 May;25(5):433-55. PMID: 22082334
  54. Clinical utility of Non-Invasive Fetal Trisomy (NIFTY) test- Early experience Lau TK, Chan MK, Connie Chan HY, Kim Chan WS, Koo TY, Joyce Ng HY, Pooh RK, Salome Lo PS J Matern Fetal Neonatal Med. 2012 Oct;25(10):1856-9. PMID: 22471583
  55. Three-dimensional/Four-dimensional Sonography moved Prenatal Diagnosis of Fetal Anomalies from the Second to the First trimester of Pregnancy Pooh RK, Kurjak A Donald School Journal of Ultrasound in Obstetrics and Gynecology, October-December. 2012;6(4):376-390. DOI: 10.5005/jp-journals-10009-1260
  56. Prenatal molecular diagnosis of a severe type of L1 syndrome (X-linked hydrocephalus) Yamasaki M, Nonaka M, Suzumori N, Nakamura H, Fujita H, Namba A, Kamei Y, Yamada T, Pooh RK, Tanemura M, Sudo N, Nagasaka M, Yoshioka E, Shofuda T, Kanemura Y J Neurosurg Pediatr. 2011 Oct;8(4):411-6. PMID: 21961551
  57. 3D and 4D sonography and magnetic resonance in the assessment of normal and abnormal CNS development: alternative or complementary Pooh RK, Kurjak A J Perinat Med. 2011 Jan;39(1):3-13. PMID: 20979445
  58. Imaging of the human embryo with magnetic resonance imaging microscopy and high-resolution transvaginal 3-dimensional sonography: human embryology in the 21st century Pooh RK, Kohei Shiota, Kurjak A American Journal of Obstetrics & Gynecology. 2011;204(1):77-9.
  59. Collaborative Study on 3-Dimensional Sonography for the Prenatal Diagnosis of Central Nervous System Defects Giuseppe Rizzo, Alfred Z. Abuhamad, Beryl R. Benaceraff, Rabih Chaoui, Edgardo Corral, Vincenzo D'Addario, Jimmy Espinoza, Wesley Lee, Louis Merce, Ritsuko Pooh, Waldo Sepulveda, Elena Sinkovskaya, Fernando Viñals, Paolo Volpe, Maria Elena Pietrolucci, Domenico Arduini J Ultrasound Med. 2011; 30:1003-1008. PMID: 21705734
  60. An Attempt to Standardize Kurjak’s Antenatal Neurodevelopmental Test: Osaka Consensus Statement Milan Stanojevic, Amira Talic, Berivoj Miskovic, Oliver Vasilj, Afaf Naim Shaddad, Badreldeen Ahmed, Aida Salihagic Kadic, Maja Predojevic, Radu Vladareanu, Daniela Lebit, Salwa Abu-Yaqoub Madeeha Al-Noobi, Ritsuko K Pooh Donald School Journal of Ultrasound in Obstetrics and Gynecology, October-December. 2011;5(4):317-329. DOI: 10.5005/jp-journals-10009-1209
  61. Classification of pathogenic or benign status of CNVs detected by microarray analysis Leung TY, Pooh RK, Wang CC, Lau TK, Choy KW Expert Rev Mol Diagn. 2010 Sep;10(6):717-21. PMID: 20843196
  62. Fetal Brain Vascularity Visualized by Conventional 2D and 3D Doppler Technology Pooh RK, Kurjak A Donald School Journal of Ultrasound in Obstetrics and Gynecology. 2010;4(3):249-258. DOI: 10.5005/jp-journals-10009-1147
  63. The potential of 4D sonography in the assessment of fetal neurobehavior--multicentric study in high-risk pregnancies Kurjak A, Abo-Yaqoub S, Stanojevic M, Yigiter AB, Vasilj O, Lebit D, Shaddad AN, Ahmed B, Kavak ZN, Miskovic B, Vladareanu R, Barisic LS, Azumendi G, Younis M, Pooh RK, Kadic AS J Perinat Med. 2010;38(1):77-82. PMID: 20047526
  64. Detailed multigrade evaluation of fetal disorders with the quantified actocardiogram Maeda K, Iwabe T, Yoshida S, Ito T, Minagawa Y, Morokuma S, Pooh RK, Fuchiwaki T J Perinat Med. 2009;37(4):392-6. PMID: 19290849
  65. Recent Advances in 3D Assessment of Various Fetal Anomalies Pooh RK, Kurjak A Donald School Journal of Ultrasound in Obstetrics and Gynecology. 2009;3(3):1-23. DOI: 10.5005/jp-journals-10009-1017
  66. Advances in Visualization of the Early Human Development Lausin I, Kurjak A, Pooh RK, Azumendi G, Maeda K Donald School Journal of Ultrasound in Obstetrics and Gynecology. 2009;3(3):25-38. DOI: 10.5005/jp-journals-10009-1018
  67. Fetal Neuroimaging Pooh RK, Pooh KH Fetal and Maternal Medicine Review, 19;1-31,. 2008 Cambridge University Press. DOI: 10.1017/s0965539508002106
  68. Fetal Ventriculomegaly Pooh RK, Kyonghon Pooh* Donald school J Ultrasound Obstet Gynecol,. 2007, 2(2):40-46.
  69. Abnormalities in the First Half of Pregnancy Pooh RK, Maeda K, Kurjak A Donald School Atlas of Fetal Anomalies. Kurjak A, Chervenak FA, Carrera JM eds. 2006:79-88
  70. Special section of UROG proposed by Japanese Ian Donald Inter-University School Maeda K, Pooh RK Ultrasound Rev Obstet Gynecol. 2006;6:107-108.
  71. Fetal Neuroimaging by transvaginal 3D ultrasound and MRI Pooh RK, Nagao Y, Pooh KH Ultrasound Rev Obstet Gynecol. 2006;6:123-134. DOI: 10.3109/14722240600786842
  72. Fetal behavior analyzed by ultrasonic actocardiogram in cases with central nervous system lesions Maeda K, Morokuma S, Yoshida S, Ito T, Pooh RK, Serizawa M J Perinat Med. 2006;34(5):398-403. PMID: 16965227
  73. Structural and functional early human development assessed by three-dimensional and four-dimensional sonography Kurjak A, M.D., Ph.D.,a Ritsuko K. Pooh, M.D., Ph.D.,b Luis T. Merce, M.D.c,Jose M. Carrera, M.D., Ph.D.,d Aida Salihagic-Kadic, M.D., Ph.D.,e and Wiku Andonotopo, M.D.f Fertil Steril. 2005 Nov;84(5):1285-99. Review. PMID: 16275217
  74. Fetal vertebral structure detected by three-dimensional ultrasound Pooh RK, Pooh KH The Ultrasound Review of Obstetrics and Gynecology, March. 2005; 5(1): 29-33.
  75. B-flow and B-flow Spatio-Temporal Image Correlation in Visualizing Fetal Cardiac Blood Flow Pooh RK, Korai A Croat Med J. 2005;46:808-11. PMID: 16158476
  76. Normal and abnormal fetal hand positioning and movement in early pregnancy detected by three-and four-dimensional ultrasound Pooh RK, T.Ogura The Ultrasound Review of Obstetrics and Gynecology,. 2004;4:46-51. DOI: 10.3109/14722240410001700249
  77. Fetal Central Nervous System Pooh RK, Kyong H Pooh Donald School Textbook of Ultrasound in Obstetrics & Gynecology,2003;250-271
  78. The assessment of fetal brain morphology and circulation by transvaginal 3D sonography and power Doppler Pooh RK, Pooh KH J Perinat Med. 2002;30(1):48-56. PMID: 11933655
  79. Transvaginal 3D and Doppler ultrasonography of the fetal brain Pooh RK, Pooh KH Semin Perinatol. 2001;25:38-43.
  80. New application of B-flow sono-angiography in perinatology Pooh RK Ultrasound Obstet Gynecol. 2000 Feb;15(2):163. PMID: 10776004
  81. Clinical Application of Three-dimensional Ultrasound in Fetal Brain Assessment Pooh RK, Pooh KH, Nakagawa Y, Nishida S, Ohno Y Croat Med J. 2000;41:245-251.
  82. Transvaginal Doppler Assessment of Fetal Intracranial Venous Flow Pooh RK, Pooh KH, Nakagawa Y, Maeda K, Fukui R, Aono T Obstet Gynecol. 1999 May;93(5 Pt 1):697-701. PMID: 10912970
  83. Fetal craniofacial structure and intracranial morphology in a case of Apert syndrome Pooh RK, Nakagawa Y, Pooh KH, Nakagawa Y, Nagamachi N Ultrasound Obstet Gynecol. 1999 Apr;13(4):274-80. PMID: 10341409
  84. Sonographic Assessment of Fetal brain Morphology Pooh RK, Maeda K, Pooh KH, Kurjak A Prenat Neonat Med. 1999;4:18-38. PMID: 11933655
  85. Transvaginal sonography of the fetal brain: detection of abnormal morphology and circulation Pooh RK, Nakagawa Y, Nagamachi N, Pooh KH, Nakagawa Y, Maeda K, Fukui R, Aono T Croat Med J. 1998 Jun;39(2):147-57. PMID: 9575270
  86. Interesting findings in early sonographic detection Pooh RK, Nakagawa Y, Nagamachi N Adv Obstet Perinatol. 1998;9:59-73.
  87. Recent advances in perinatal sonography Kurjak A, Kupesic S, Di Renzo GC, Pooh RK, Kos M and Hafner T Prenat Neonat Med. 1998;3:194-207.
  88. Multicystic dysplastic kidney: Report of five cases Ogino N, Pooh RK, Endo S, Mitani R, Maeda K, Fukui R Adv Obstet Perinatol. 1998;9:89-99.
  89. Transvaginal power Doppler angiography of the fetal brain Pooh RK and T. Aono Ultrasound Obstet Gynecol. 1996 Dec;8(6):417-21.
  90. First-Trimester Detection of Conotruncal Anomalies Using Transabdominal SlowflowHD: A Case Series and Proof-of-Concept Study Fukuda H, Fukuda A, Mimura K, Endo M, Pooh RK, Kodama M J Ultrasound Med. 2025 Aug 19. PMID: 40827753 DOI: 10.1002/jum.70037
  91. Effect of aspirin on small for gestational age neonates in pregnancies at high-risk for preeclampsia: a secondary analysis of a cluster randomised clinical trial Chen Y, Nguyen-Hoang L, Dinh LT, Nguyen DA, Pooh RK, Shiozaki A, Zheng M, Hu Y, Ma R, Kusuma A, Wataganara T, Choolani MA, Kaneko M, Luewan S, Chang TY, Chaiyasit N, Nanthakomon T, Jiang Y, Shaw SW, Leung WC, Mohamad AS, Aguilar A, Lau SL, Lee NMW, Liu J, Sahota DS, Chong MKC, Papastefanou I, Poon LC Lancet Reg Health West Pac. 2025 Jun 5;59:101582. ; PMCID: PMC12173081. PMID: 40529816 DOI: 10.1016/j.lanwpc.2025.101582
  92. Open isthmus and lambda (Λ) sign of early Joubert syndrome: elucidating development of molar tooth sign RK Pooh, M Takeda, K Itoh, J Yoshimatsu, K Ogo, M Machida, H Ohashi,O Shimokawa Ultrasound Obstet Gynecol. 2024 Apr 20. PMID: 38642341 DOI: 10.1002/uog.27666
  93. Aortic Dissection and a Previously Unreported ACTA2 Missense Variant Mutation in a Young Patient: A Case Report Marutani S, Nishino T, Shimokawa O, Pooh RK, Morisaki H, Inamura N Pediatr Dev Pathol. 2023 Sep 6:10935266231194701. PMID: 37672683 DOI: 10.1177/10935266231194701
  94. Compound heterozygous variants in RAB34 in a rare skeletal ciliopathy syndrome Batkovskyte D, Komatsu M, Hammarsjö A, Pooh RK, Shimokawa O, Ikegawa S, Grigelioniene G, Nishimura G, Yamada T Clin Genet. 2023 Aug 24. PMID: 37619988 DOI: 10.1111/cge.14419
  95. Somatic mosaicism of the PI3K-AKT-MTOR pathway is associated with hemimegalencephaly in fetal brains Itoh K, Pooh RK, Shimokawa O, Fushiki S Neuropathology. 2022 Nov 3. Epub ahead of print. PMID: 36325654 DOI: 10.1111/neup.12875
  96. First-trimester pre-eclampsia biomarker profiles in Asian population: a multicenter cohort study Chaemsaithong P, Sahota D, Pooh RK, Zheng M, Ma R, Chaiyasit N, Koide K, Shaw SW, Seshadri S, Choolani M, Panchalee T, Yapan P, Sim WS, Sekizawa A, Hu Y, Shiozaki A, Saito S, Leung TY, Poon LC Ultrasound Obstet Gynecol. 2019 Oct 31. PMID: 31671479 DOI: 10.1002/uog.21905
  97. Prospective evaluation of screening performance of first trimester prediction models for preterm preeclampsia in Asian population Chaemsaithong P, Pooh RK, Zheng M, Ma R, Chaiyasit N, Tokunaka M, Shaw SW, Seshadri S, Choolani M, Wataganara T, Yeo GSH, Wright A, Leung WC, Sekizawa A, Hu Y, Naruse K, Saito S, Sahota D, Leung TY, Poon LC Am J Obstet Gynecol. 2019 Oct 4. pii: S0002-9378(19)31207-4. DOI: 10.1016/j.ajog.2019.09.041
  98. Type-3 vasa previa: normal umbilical cord insertion is not enough to exclude vasa previa in cases with abnormal placental location Suekane T, Tachibana D, Pooh RK, Misugi T, Koyama M Ultrasound Obstet Gynecol. 2019 May 22. PMID: 31115101 DOI: 10.1002/uog.20347
  99. Utility of the STIC method for diagnosing tachyarrhythmia in fetuses at 12 weeks' gestational age Inamura N, Pooh RK Ultrasound Obstet Gynecol. 2019 May 13. PMID: 31081557 DOI: 10.1002/uog.20345
  100. Prenatal diagnosis of dural sinus malformation in a fetus presenting with general oedema Lipa M, Kosinski P, Pooh RK, Wielgos M Ultrasound Obstet Gynecol. 2017 Jul 25. PMID: 28741709 DOI: 10.1002/uog.18818
  101. Is intrauterine surgery justified? Report from the working group on ultrasound in obstetrics of the World Association of Perinatal Medicine (WAPM) Moreira de Sá RA, Nassar de Carvalho PR, Kurjak A, Adra A, Dayyabu AL, Ebrashy A, Pooh RK, Sen C, Wataganara T, Stanojevic M Journal of Perinatal Medicine,. 2016 Oct 1;44(7):737-743. PMID: 26124046 DOI: 10.1515/jpm-2015-0132
  102. Current topics on ultrasound in perinatology Pooh RK J Perinat Med. 2016 Mar 1;44(2):117-8. PMID: 26959534
  103. Sonoembryology by 3D HDlive silhouette ultrasound - what is added by the "see-through fashion"? Pooh RK J Perinat Med. 2016 Mar 1;44(2):139-48. PMID: 26910738
  104. Non-invasive prenatal screening of fetal sex chromosomal abnormalities: perspective of pregnant women Lau TK, Chan MK, Lo PS, Chan HY, Chan WK, Koo TY, Ng HY, Pooh RK J Matern Fetal Neonatal Med. 2012 Aug 10. PMID: 22839575
  105. Prenatal diagnosis of Costello syndrome using 3D ultrasonography amniocentesis confirmation of the rare HRAS mutation G12D Kuniba H, Pooh RK, Sasaki K, Shimokawa O, Harada N, Kondoh T, Egashira M, Moriuchi H, Yoshiura K, Niikawa N Am J Med Genet A. 2009 Feb 15;149A(4):785-7. PMID: 18642361

Review Articles

  1. First-trimester preterm preeclampsia prediction model for prevention with low-dose aspirin Pooh RK J Obstet Gynaecol Res. 2024. PMID: 38366809 DOI: 10.1111/jog.15908
  2. Fetal 24-Segment Sphericity Index and Ventricular Fractional Shortening Between 12 and 20 Weeks of Gestation Inamura N, Machida M, Nakamura T, Uenishi K, Pooh RK J Ultrasound Med. 2024. PMID: 38923585 DOI: 10.1002/jum.16516
  3. Malformations of Cortical Development (MCDs) Pooh RK Ultrasound in Obstetrics and Gynecology, Fetal Neurosonography, De Robertis V (Ed.), Springer, 2024. DOI: 10.1007/978-3-031-70192-4
  4. Prenatal diagnosis of bone dysplasias Nishimura G, Handa A, Miyazaki O, Tsujioka Y, Murotsuki J, Sawai H, Yamada T, Kozuma Y, Takahashi Y, Ozawa K, Pooh RK, Sase M Br J Radiol. 2023 Jul;96(1147):20221025. PMID: 37351952 DOI: 10.1259/bjr.20221025
  5. Central Nervous System Malformations D'Addario V, Pooh RK Donald School Basic Textbook of Ultrasound in Obstetrics and Gynecology. 2023.
  6. Central Nervous System Malformations D’Addario V, Pooh RK Donald School Basic Textbook of Ultrasound in Obstetrics and Gynecology, Third Edition, D’Addario V , Kurjak A, Rizzo G, Eds., Jaypee Brothers Medical Publishers, New Delhi, 2023, Chapter7. 70-98
  7. First trimester examination of fetal anatomy: clinical practice guideline by the World Association of Perinatal Medicine (WAPM) and the Perinatal Medicine Foundation (PMF) Volpe N, Sen C, Turan S, Sepulveda W, Khalil A, Rolnik D, De Robertis V, Volpe P, Gil MM, Chaveeva P, Dagklis T, Pooh RK, Kozinski P, Cruz J, Huertas E, D' Antonio F, Rodrigues Calvo J, Daneva Markova A Perinatal Journal. 2022;30(2):87-102doi: 10.1515/jpm-2022-0125. PMID: 35452577
  8. Fetal Brain Structure and CNS Anomalies Pooh RK, Machida M, Matsuzawa N Donald School J Ultrasound Obstet Gynecol. 2022; 16 (1):31-52. DOI: 10.5005/jp-journals-10009-1921
  9. WAPM-World Association of Perinatal Medicine practice guidelines: fetal central nervous system examination Valentina De Robertis, Cihat Sen, Ilan Timor-Tritsch, Rabih Chaoui, Paolo Volpe, Alberto Galindo, Reuven Achiron, Ritsuko Pooh, Asma Khalil, Nicola Volpe, Francesco D’Antonio and Roee Birnbaum De Gruyter | Published online: June 3,. 2021. PMID: 34087958 DOI: 10.1515/jpm-2021-0183
  10. Recent Fetal Neurology: From Neurosonography to Neurosonogenetics Pooh RK Donald School Journal of Ultrasound in Obstetrics and Gynecology, Volume 15 Issue 3 (July–September. 2021). 229-239. DOI: 10.5005/jp-journals-10009-1718
  11. Sonoembryology Pooh RK Donald School Embryo as a Person and as a Patient, First Edition, Kurjak A, Frank A Chervenak, Eds., Jaypee Brothers Medical Publishers, New Delhi, 2020, Chapter3, pp19-27
  12. Three-dimensional Evaluation of the Fetal Brain Pooh RK Donald School The Fetus as a Patient: Current Perspectives, Kurjak A, Plavsic SK, Chervenak FA, Eds., Jaypee Brothers Medical Publishers, New Delhi, 2020, Chapter18, pp234-241.
  13. Neuroimaging and Genetics in Brain Maldevelopment Pooh RK Fetal Morph Functional Diagnosis (Comprehensive Gynecology and Obstetrics), Hideaki M (Ed.), Springer, 2020, PartIII Genetic Disorders, pp81-102.
  14. HDliveFlow silhouette mode for diagnosis of ectopia cordis with left ventricular diverticulum at 15 weeks of gestation Hata T, Ito M, Nitta E, Pooh RK, Sasahara J, Inamura N Journal of Ultrasound in Medicine,. 2018;00:00–00. PMID: 29528126 DOI: 10.1002/jum.14583
  15. Prenatal diagnosis of dural sinus malformation in fetus presenting with edema Michal L, Przemyslaw K, Pooh RK, Miroslaw W Ultrasound Obstet Gynecol. 2018; 51: 841–842 Published online in Wiley Online Library (wileyonlinelibrary.com). PMID: 28741709 DOI: 10.1002/uog.18818
  16. HDlive Silhouette and HDlive Flow: New Application of 3D Ultrasound in Prenatal Diagnosis Pooh RK Donald School Textbook of Ultrasound in Obstetrics and Gynecology, 4th Ed., Kurjak A, Chervenak FA eds. Jaypee Brothers Medical Publishers, New Delhi, 2017, Chapter7, pp88-105. DOI: 10.5005/jp/books/13058_8
  17. Fetal Central Nervous System Pooh RK Donald School Textbook of Ultrasound in Obstetrics and Gynecology, Fourth Edition, Kurjak A, Frank A Chervenak, Eds., Jaypee Brothers Medical Publishers, New Delhi, 2017, Chapter17. Pp222-271 DOI: 10.5005/jp/books/11213_16
  18. Three-dimensional Sonoembryology Pooh RK, Shiota K, Kurjak A Donald School Textbook of Ultrasound in Obstetrics and Gynecology, Fourth Edition, Kurjak A, Frank A Chervenak, Eds., Jaypee Brothers Medical Publishers, New Delhi, 2017, Chapter32, pp515-551
  19. Three-dimensional Ultrasound in Detection of Fetal Anomalies Pooh RK, Kurjak A Donald School Textbook of Ultrasound in Obstetrics and Gynecology, Fourth Edition, Kurjak A, Frank A Chervenak, Eds., Jaypee Brothers Medical Publishers, New Delhi, 2017, Chapter34, pp609-641 DOI: 10.5005/jp/books/13058_35
  20. Three-dimensional Evaluation of the Fetal Brain Pooh RK Donald School Journal of Ultrasound in Obstetrics and Gynecology, October-December. 2017;11(4): 268-275. DOI: 10.5005/jp-journals-10009-1532
  21. Antenatal Detection of Fetal Syndromes by Ultrasound From a Single Piece to a Complete Puzzle Barisic LS, Kurjak A, Pooh RK, Delic T, Stanojevic M, Porovic S Donald School Journal of Ultrasound in Obstetrics and Gynecology, January-March. 2016; 10(1): 63-77. DOI: 10.5005/jp-journals-10009-1444
  22. Twenty-week Brain Vascularity by Transvaginal 3D HDlive Flow Pooh RK Donald School Journal of Ultrasound in Obstetrics and Gynecology, July-September. 2016;10(3): 203-204. DOI: 10.5005/jp-journals-10009-1469
  23. Malformations of the Central Nervous System Pooh RK Donald School Basic Textbook of Ultrasound in Obstetrics and Gynecology. 2015.
  24. Brand New Technology of HDlive Silhouette and HDlive Flow Images Pooh RK, Kurjak A Donald School Atlas of Advanced Ultrasound in Obstetrics and Gynecology. 2015.
  25. Early Normal Pregnancy (Before 11 Weeks) Pooh RK, Kurjak A Donald School Atlas of Advanced Ultrasound in Obstetrics and Gynecology, Pooh RK, Kurjak A eds. Jaypee Brothers Medical Publishers, India, 2015.
  26. Early Abnormal Pregnancy (Before 11 Weeks) Pooh RK, Kurjak A Donald School Atlas of Advanced Ultrasound in Obstetrics and Gynecology, Pooh RK, Kurjak A eds. Jaypee Brothers Medical Publishers, India, 2015.
  27. Normal Fetus in the 1st Trimester (11 to 13+6 Weeks) Pooh RK, Kurjak A Donald School Atlas of Advanced Ultrasound in Obstetrics and Gynecology, Pooh RK, Kurjak A eds. Jaypee Brothers Medical Publishers, India, 2015.
  28. Fetal Abnormality in the 1st Trimester (11≤13+6 Weeks) Pooh RK, Kurjak A Donald School Atlas of Advanced Ultrasound in Obstetrics and Gynecology, Pooh RK, Kurjak A eds. Jaypee Brothers Medical Publishers, India, 2015.
  29. Normal and Abnormal Placenta, Membranes and Cord in the 1st Trimester (≤13+6 Weeks) Pooh RK, Kurjak A Donald School Atlas of Advanced Ultrasound in Obstetrics and Gynecology, Pooh RK, Kurjak A eds. Jaypee Brothers Medical Publishers, India, 2015.
  30. Late Abnormalities in the 2nd and 3rd Trimesters (≥14+0 Weeks) Pooh RK, Kurjak A Donald School Atlas of Advanced Ultrasound in Obstetrics and Gynecology, Pooh RK, Kurjak A eds. Jaypee Brothers Medical Publishers, India, 2015.
  31. Sonoembryology Pooh RK Wataganara T, Pooh RK, Kurjak A. Donald School Textbook of PowerPoint Presentation on Advanced Ultrasound in Obstetrics & Gynecology. Jaypee Brothers Medical Publishers, India, 2015, pp1-4
  32. Fetal Neuroanatomy by ultrasound Pooh RK Wataganara T, Pooh RK, Kurjak A. Donald School Textbook of PowerPoint Presentation on Advanced Ultrasound in Obstetrics & Gynecology. Jaypee Brothers Medical Publishers, India, 2015, pp53-55
  33. Fetal Neuropathology Pooh RK Wataganara T, Pooh RK, Kurjak A. Donald School Textbook of PowerPoint Presentation on Advanced Ultrasound in Obstetrics & Gynecology. Jaypee Brothers Medical Publishers, India, 2015, pp56-59
  34. Donald School Textbook of PowerPoint Presentation on Advanced Ultrasound in Obstetrics & Gynecology Pooh RK. Fetal skeletall dysplasia and malformation. In Wataganara T, Pooh RK, Kurjak A Jaypee Brothers Medical Publishers, India, 2015, pp243-245 DOI: 10.5005/jp/books/12692
  35. Sonogenetics Pooh RK Wataganara T, Pooh RK, Kurjak A. Donald School Textbook of PowerPoint Presentation on Advanced Ultrasound in Obstetrics & Gynecology. Jaypee Brothers Medical Publishers, India, 2015, pp246-248
  36. First Trimester Scan by 3D, 3D HDlive and HDlive Silhouette/Flow Ultrasound Imaging Pooh RK Donald School Journal of Ultrasound in Obstetrics and Gynecology, October-December 2015; 9(4): pp361-371
  37. Continuous Medical Education on Obstetrics and Gynecology Ultrasound : Asian Experience Pooh RK Donald School Journal of Ultrasound in Obstetrics and Gynecology, January-March 2014; 8(1): pp65-71 DOI: 10.5005/jp-journals-10009-1336
  38. Lifelong Learning, Psychotropic Medication Use during Pregnancy and Lactation: Role of Ultrasound Assessment Andrew Matthys, Maria Ambat, Ritsuko Pooh, Sanja Kupesic Plavsic Donald School Journal of Ultrasound in Obstetrics and Gynecology, January-March 2014; 8(1): pp109-121 DOI: 10.5005/jp-journals-10009-1345
  39. Early Detection of Fetal Abnormality Pooh RK Donald School Journal of Ultrasound in Obstetrics and Gynecology, January-March 2013, Vol 7(1): pp46-50 DOI: 10.5005/jp-journals-10009-1269
  40. Global Activity of Ian Donald Ultrasound Education Pooh RK, Kurjak A Donald School Journal of Ultrasound in Obstetrics and Gynecology, July-September 2013; 7(3): pp323-328 DOI: 10.5005/jp-journals-10009-1300
  41. Assessment of Fetal Central Nervous System Pooh RK, Pooh KH Donald School Journal of Ultrasound in Obstetrics and Gynecology, October-December 2013; 7(4): pp369-384 DOI: 10.5005/jp-journals-10009-1308
  42. Lifelong Learning, The Role of Ultrasound in the Diagnosis of Complications Associated with Maternal Diabetes Kallie Appleton, Jami Barnard, Adam K Jantz, Ritsuko Pooh, Carmina Comas-Gabriel, Sanja Kupesic-Plavsic Donald School Journal of Ultrasound in Obstetrics and Gynecology, October-December 2013, 7(4): pp506-515 DOI: 10.5005/jp-journals-10009-1325
  43. Fetal neurology: Volume I Pooh RK Semin Fetal Neonatal Med. 2012 Oct;17(5):251.
  44. Normal anatomy by three-dimensional ultrasound in the second and third trimesters Pooh RK Semin Fetal Neonatal Med. 2012 Oct;17(5):269-77. PMID: 22817865
  45. Imaging diagnosis of congenital brain anomalies and injuries Pooh RK Semin Fetal Neonatal Med. 2012 Aug 29. PMID: 22939613
  46. Sonogenetics in fetal neurology Pooh RK Semin Fetal Neonatal Med. 2012 Aug 21. PMID: 22921277
  47. Molecular genetics in fetal neurology Huang J, Wah IY, Pooh RK, Choy KW Semin Fetal Neonatal Med. 2012 Aug 18. PMID: 22909903
  48. Fetal neurology: Volume II Pooh RK Semin Fetal Neonatal Med. 2012 Aug 1.
  49. Neurosonoembryology by three-dimensional ultrasound Pooh RK Seminars in Fetal and Neonatal Medicine Vol. 17/5 (2012) 251-308: Fetal neurology: Volume 1, pp261-268 PMID: 22800609
  50. Normal anatomy by three-dimensional ultrasound in the second and third trimesters Pooh RK Seminars in Fetal and Neonatal Medicine Vol. 17/5 (2012) 251-308: Fetal neurology: Volume 1, pp269-277 PMID: 22817865
  51. Editorial Pooh RK Fetal neurology: Volume 1. Seminars in Fetal and Neonatal Medicine Vol. 17/5 (2012) 251-308: Fetal neurology: Volume 1, pp251 PMID: 22858593
  52. 3D Sonoembryology Pooh RK Donald school Journal of Ultrasound in Obstetrics and Gynecology, January-March 2011, Volume 5, Number 1: pp 7-15, Jaypee, India
  53. Fetal Neuroimaging by Transvaginal 3D Ultrasound and MRI Pooh RK, KyongHon Pooh Donald school Journal of Ultrasound in Obstetrics and Gynecology, January-March 2011, Volume 5, Number 1: pp 23-32, Jaypee, India DOI: 10.5005/jp-journals-10009-1173
  54. Sonogenetics: A Breakthrough in Prenatal Diagnosis Pooh RK, Kwang Wai Choy, Leung Tak Yeung, Tze Kin Lau Donald school Journal of Ultrasound in Obstetrics and Gynecology, January-March 2011, Volume 5, Number 1: pp 73-77, Jaypee, India DOI: 10.5005/jp/books/12692_27
  55. Contribution of Transvaginal High-Resolution Ultrasound in Fetal Neurology Pooh RK Donald school Journal of Ultrasound in Obstetrics and Gynecology, April-June & July-Sept. 2011, Volume 5, Number 2 & 3: pp 93-99, Jaypee, India DOI: 10.5005/jp-journals-10009-1183
  56. Fetal Central Nervous System Pooh RK, Kyong Hon Pooh Donald School Textbook of Ultrasound in Obstetrics and Gynecology,Third Edition, Kurjak A, Frank A Chervenak, Eds., Jaypee Brothers Medical Publishers, New Delhi, 2011 pp233-276 DOI: 10.5005/jp/books/11213_16
  57. Three-Dimensional Sonoembryology Pooh RK, Kohei Shiota, Kurjak A Donald School Textbook of Ultrasound in Obstetrics and Gynecology,Third Edition, Kurjak A, Frank A Chervenak, Eds., Jaypee Brothers Medical Publishers, New Delhi, 2011 pp540-558
  58. 3D Ultrasound in Detection of Fetal Anomalies Pooh RK, Kurjak A Donald School Textbook of Ultrasound in Obstetrics and Gynecology,Third Edition, Kurjak A, Frank A Chervenak, Eds., Jaypee Brothers Medical Publishers, New Delhi, 2011 pp621-639 DOI: 10.5005/jp/books/11213_35
  59. Classification of pathogenic or benign status of CNVs detected by microarray analysis Leung TY, Pooh RK, Wang CC, Lau TK, Choy KW Expert Rev Mol Diagn. 2010 Sep;10(6):717-21. PMID: 20843196
  60. Neuroanatomy Visualized by 2D and 3D Pooh RK Fetal Neurology, Pooh RK, Kurjak A eds. Jaypee Brothers Medical Publishers, India, 2009. DOI: 10.5005/jp/books/10305_3
  61. Normal and Abnormal Brain Vascularity Pooh RK, Kurjak A, Tikvica A Fetal Neurology, Pooh RK, Kurjak A eds. Jaypee Brothers Medical Publishers, India, 2009. DOI: 10.5005/jp/books/10305_2
  62. Neuroscan of Congenital Brain Abnormality Pooh RK Fetal Neurology, Pooh RK, Kurjak A eds. Jaypee Brothers Medical Publishers, India, 2009. DOI: 10.5005/jp/books/10305_3
  63. Neuroscan of Normal and Abnormal Vertebrae and Spinal Cord Pooh RK, Kurjak A Fetal Neurology, Pooh RK, Kurjak A eds. Jaypee Brothers Medical Publishers, India, 2009. DOI: 10.5005/jp/books/10305_4
  64. Assessment of Fetal Neurobehavior By 3D/4D Sonography Kurjak A, Pooh RK, Tikvica A, Stanojevic M, Miskovic B, Ahmed B, Azumendi G Fetal Neurology, Pooh RK, Kurjak A eds. Jaypee Brothers Medical Publishers, India, 2009. DOI: 10.5005/jp/books/10305_5
  65. Fetal Behavior in High-risk Pregnancies Kurjak A, Pooh RK, Tikvica A, Miskovic B, Stanojevic M, Ahmed B Fetal Neurology, Pooh RK, Kurjak A eds. Jaypee Brothers Medical Publishers, India, 2009. DOI: 10.5005/jp/books/10305_7
  66. Normal and Abnormal Fetal Hands/Fingers Positioning and Movement in the First Half of Pregnancy Pooh RK, Kurjak A, Ogura T Fetal Neurology, Pooh RK, Kurjak A eds. Jaypee Brothers Medical Publishers, India, 2009. DOI: 10.5005/jp/books/10305_8
  67. Molecular Genetics and Fetal Brain Stavljenic-Rukavina A, Kurjak A, Pooh RK Fetal Neurology, Pooh RK, Kurjak A eds. Jaypee Brothers Medical Publishers, India, 2009. DOI: 10.5005/jp/books/10305_9
  68. Molecular Genetics and Fetal Brain Stavljenic-Rukavina A, Kurjak A, Pooh RK Fetal Neurology, Pooh RK, Kurjak A, Jaypee Brothers Medical Publishers, New Delhi, 2009 pp453-483 DOI: 10.5005/jp/books/10305_16
  69. Acquired brain abnormalities in utero Pooh RK, Maeda K, Pooh KH An Atlas of Fetal Central Nervous System Disease, Pooh RK, Maeda K, Pooh KH eds. 2008.
  70. Antenatal assessment of CNS anomalies, including neural tube defects Pooh RK, Pooh KH Fetal and Neonatal Neurology and Neurosurgery, 4th Edition. 2008. DOI: 10.1016/j.cult.2008.09.007
  71. Fetal Central Nervous System Pooh RK Donald School Basic Textbook of Ultrasound in Obstetrics and Gynecology, Ahmed B, Adra A, Kavak ZN, Eds., Jaypee Brothers Medical Publishers, New Delhi, 2008 pp326-349 DOI: 10.5005/jp/books/11213_16
  72. Evaluacion de la posicion y movimientos de manos y dedos al inicio de la gestacion mediante ecografia transvaginal 3D y 4D Pooh RK, Ogura T Conducta fetal Estudio ecografico de la neurologia fetal, Carrera JM, Kurjak A, Eds. Elsevier, 2008, pp87-96
  73. Clasificacion de la conducta fetal y gravedad de las lesiones del sistema nervioso central fetal evaluadas por el actocardiograma cuantitativo Maeda K, Morokuma S, Yoshida S, Ito T, Pooh RK, Serizawa M, Fuchiwaki T Conducta fetal Estudio ecografico de la neurologia fetal, Carrera JM, Kurjak A, Eds. Elsevier, 2008, pp241-251 DOI: 10.61182/rnavmed.v2n2a5
  74. Anatomia normal y defectos estructurales del sistema nervioso central Pooh RK, Pooh KH Ecografia en diagnostico prenatal, Carrera JM, Kurjak A, Eds. Elsevier, 2008, pp173-192 DOI: 10.1016/b978-84-458-1845-9.50013-x
  75. Congenital brain anomalies Pooh RK, Pooh KH An Atlas of Fetal Central Nervous System Disease: Diagnosis and Management, Pooh RK, Maeda K, Pooh KH eds. 2007.
  76. Normal and Abnormal Early Human Structural Development Pooh RK, Kurjak A The Fetus in Three Dimensions, Imaging, Embryology and Fetoscopy. Kurjak A, Azumendi G eds. Informa Healthcare, London, 2007. DOI: 10.5005/jp/books/10227_6
  77. Hydrocephalus and ventriculomegaly Pooh RK, Pooh KH An Atlas of Fetal Central Nervous System Disease: Diagnosis and Management, Pooh RK, Maeda K, Pooh KH eds. 2006.
  78. Structural and functional early human development assessed by three-dimensional and four-dimensional sonography Kurjak A, Pooh RK, Merce LT, Carrera JM, Salihagic-Kadic A, Andonotopo W Fertil Steril. 2005 Nov;84(5):1285-99. PMID: 16275217
  79. Imaging of the normal fetal central nervous system Pooh RK An Atlas of Fetal Central Nervous System Disease: Diagnosis and Management, Pooh RK, Maeda K, Pooh KH eds. Parthenon Publishing, New York, London, 2003-2005.
  80. Early Detection of Fetal Abnormality Pooh RK Donald School Textbook of Transvaginal Sonography 2005;74-83 DOI: 10.5005/jp/books/10230_9
  81. Assessment of Fetal Central Nervous System Pooh RK, Pooh KH Donald School Textbook of Transvaginal Sonography 2005;105-124 DOI: 10.5005/jp/books/10230_12
  82. Fetal Upper Limb Movement in the First Half of Pregnancy Detected by Transvaginal 4D Ultrasound Pooh RK, Ogura T Donald School Textbook of Transvaginal Sonography. 2005:492-499. DOI: 10.5005/jp/books/10230_39
  83. Fetal Central Nervous System Pooh RK, KyongHon Pooh* Textbook of Perinatal Medicine, 2005 DOI: 10.5005/jp/books/11213_16
  84. Structural and functional early human development as assessed by three-dimensional (3D) and four-dimensional (4D) sonography Kurjak A, Pooh RK, Merce LT, Carrera JM, Salihagic-Kadic A, Andonotopo W Fertil Steril. 2005 Nov;84(5):1285-99.
  85. Technologists and techniques of fetal neuroimaging diagnosis Pooh RK, Maeda K An Atlas of Fetal Central Nervous System Disease: Diagnosis and Management, Pooh RK, Maeda K, Pooh KH eds. Parthenon Publishing, New York, London, 2004, pp13-21.
  86. Three- and four-dimensional visualization in early pregnancy Pooh RK, Endo S, Kinoshita T, Nakayama S An Atlas of Three- and Four-Dimensional Sonography in Obstetrics and Gynecology, Kurjak A and Jackson D eds. pp59-66; Taylor & Francis, UK, 2004.
  87. Background and role of fetal central nervous system: diagnosis and management Pooh RK An Atlas of Fetal Central Nervous System Disease: Diagnosis and Management, Pooh RK, Maeda K, Pooh KH eds. Parthenon Publishing, New York, London, 2003, pp1-3. DOI: 10.3109/9780203490679-7
  88. Central nervous system development and anatomy Pooh RK An Atlas of Fetal Central Nervous System Disease: Diagnosis and Management, Pooh RK, Maeda K, Pooh KH eds. Parthenon Publishing, New York, London, 2003, pp5-12.
  89. Transvaginal three-dimensional volume assessment of the fetal brain structure Pooh RK, Pooh KH The Fetus as a Patient, The Evolving Challenge. Chervenak FA, Kurjak A, Papp Z eds. 2002:73-77.
  90. Fetal neuroimaging with new technology Pooh RK, Pooh KH The Ultrasound Review of Obstetrics and Gynecology. 2002;2:178-181.
  91. Transvaginal Ultrasound for fetal brain Pooh RK, Pooh KH J Obstet Gynaecol Res. 2001. PMID: 11254159
  92. Sonographic volumetry of small structure in early pregnancy Pooh RK The embryo as a patient. Chervenak FA, Kurjak A, Carrera JM eds. Parthenon Publishing, Carnforth, 2001:156-160.
  93. 3-D Volume Imaging and 3-D Angiography of the Fetal Brain Pooh RK, Pooh KH Proceedings of the 5th Congress of Perinatal Medicine, The Perinatal Medicine of New Millennium. Carrera JM, Cabro L, Baraibar R eds. 2001:371-374.
  94. Fetal Brain Assessment by Transvaginal US, 3-D US and MRI Pooh RK, Pooh KH Proceedings of the 5th Congress of Perinatal Medicine, The Perinatal Medicine of New Millennium. Carrera JM, Cabro L, Baraibar R eds. 2001:956-959.
  95. Fetal Brain Assessment by Three-Dimensional Ultrasound Pooh RK Clinical Application of 3D Sonography, Kurjak A, Kupesic S eds. Carnforth, UK: Parthenon Publishing, 2000:171-179.
  96. B-mode and Doppler studies of the abnormal fetus in the first trimester Pooh RK In Chervenak F, Kurjak A eds. Fetal Medicine. Parthenon Publishing, Carnforth, 1999:46-51.
  97. Two-dimensional and three-dimensional Doppler angiography in fetal brain circulation Pooh RK In Kurjak A ed. 3D Power Doppler in Obstetrics and Gynecology. Parthenon Publishing, Carnforth, 1999:105-111.
  98. Fetal CNS abnormalities: prenatal diagnosis by advanced technology of transvaginal sonography and 3D ultrasound Pooh RK The 10th Fukuoka International Symposium on Perinatal Medicine. Proceedings 1999:59-64. DOI: 10.1046/j.1469-0705.2001.0180s1026.x
  99. Fetal cranial bone formation: sonographic assessment Pooh RK 9th World Congress on Ultrasound in Obstetrics and Gynecology, Proceedings, Monduzzi Editore, Bologna, 1999:407-410.
  100. Fetal brain assessment using transvaginal sonography and power Doppler mapping Pooh RK, Aono T Modern Methods of the Assessment of Fetal and Neonatal Brain,. 1997;156-163. PMID: 9014283

Dr.ぷぅが出生前診断にかける想い

ぷぅ院長

生命誕生の不思議に魅せられ、
胎児診断専門クリニック設立へ

哲学者の父と、英文学者の母との間に次女として生まれた兵庫県育ち。中学生のときに「罪を憎んで人を憎まず」という言葉に感動して弁護士を目指して法学部へ。慶應義塾大学法学部法律学科では刑法学および生命倫理学を専攻し、生命誕生の不思議に魅せられ、継続した興味から法学部卒業後、再度医学部受験、徳島大学医学部へ進学し、卒後産婦人科医となりました。未知なる胎児の中でもとりわけ未解明な事実の多い妊娠初期の胎児発達と胎児中枢神経系に興味をもち、胎児画像診断を診療の中心としています。

1996年から始めた経腟超音波走査法による詳細な胎児脳診断は国際的にも高く評価されており、現在では、国際学会でも「胎児脳」といえばDr.ぷぅ(Dr.Pooh)の名前が当然のように出てくるようになっています。Dr.ぷぅ(Dr.Pooh)の診断画像は非常にScientificかつArtisticだと定評があり、2017年12月には米国NIH(国立衛生研究所)周産期リサーチブランチでDr.ぷぅ(Dr.Pooh)の胎児超音波画像のエキシビジョンが開かれ、多くの医療関係者が集まっています。

さらに、FMF(Fetal Medicine Foundation)のNT資格を日本で早期に取得し、2009年からシステマティックな妊娠初期の胎児診断を開始、Sonoembryology(超音波発生学)を実施臨床で確立したことで、Sonogenetics(超音波遺伝学)という新分野を提唱、国際学会で高く評価されるようになりました。2009年から開始した母体腹壁からの絨毛検査は、それまでの「絨毛検査は腟からの検査で危険で結果があいまい」という日本での概念を打ち崩し、クリフムはこれまで20,000例以上(2009年〜2025年のデータ参照)の経腹的絨毛検査を施行したエキスパートでもあります。日本人類遺伝学会認定 臨床遺伝専門医の資格を持ちながらも、日進月歩の遺伝医学をもっと学びたいと考え、2016-2018年には診療の合間をぬって香港のChinese University Hong Kong(CUHK)大学院で米国Baylor医科大学とCUHKの教授陣から遺伝医学を学び、理学修士(Master of Science)を取得。

2006年、胎児診断を究めて患者さんのサポートをするため、大好きだった分娩・手術・救急搬送などから離れて日本で初めての胎児診断専門クリニックを立ち上げました。「胎児診ずして胎児診断あらず」「胎児ファースト」の信条のもと、と毎年バージョンアップした最新の超音波機器を導入行う診断には妥協を許さない。さらに、出生前診断は診断することがゴールではなく、診断したところからが患者様に寄り添うスタート地点だというポリシーのもと、胎児病の患者様にとことん寄り添う出生前診断という、だれからも理解しやすい医療を展開し、2012年ではこの「寄り添う出生前診断」が視聴率9.6%となるNHKスペシャルの番組になりました。

2012年にはさらに遺伝カウンセリング部門をクリフムに新設し、日本人類遺伝学・細胞遺伝学の大御所である千代豪昭先生、日本人類遺伝学・分子遺伝学の大御所、松原洋一先生らがクリフム副院長に就任され、患者様の遺伝カウンセリングではさらに究極を目指せるようになりました。診断機器の技術進歩とDr.ぷぅ(Dr. Pooh)が撮影する画像は素人にも容易に理解しやすく、全国から正確な診断を求める患者が数多くクリフムを訪れています。また遺伝学的検査において、正確な表現型がいかに重要であるかということを国内・国外の学会で教授しており、国内、海外のドクターたちからも画像コンサルテーションの相談や遺伝学的な相談を受けています。

産婦人科領域のみならず、小児脳神経領域においても幅広い臨床を行っており、国内で3大学、さらに現在では米国・ロシア・クロアチアの大学の教授を併任しており、国内だけでなく、海外の学会・研究会からの講演依頼は多く、講演は年間70以上(内、2/3が英語でのプレゼンテーション)を数えます。2008年・2017年には米国NIHからの要請でアメリカにも胎児神経画像診断を教えに行ったり、胎児診断で世界を牽引するイギリスのFMFでも講演・実践での教育を行っています。アジア・ヨーロッパ・中東・アフリカなど各国からDr.ぷぅ(Dr.Pooh)の超音波講義や実技指導の要請があとを絶ちません。国内でも積極的にセミナーや学会を開催し、多くの若手医師、若手研究者からも師事されています。また、2000年に開始した「胎児ドック」の創設者でもあり、そのシステマティックな画像診断は来院患者も十分納得のいくものであり、診断テクニックを習得しようとDr.ぷぅ(Dr.Pooh)のもとを訪れる若手医師や検査技師も多く、海外の医師たちが数ヶ月単位でクリフムに留学しています。

かたい経歴のわりに気さくでユーモアあふれる性格の3児の母です。赤ちゃんを超音波で診断していく間もママと気さくにお話しして、リラックスしていただけるよう、子育ての相談にものっています。

Dr.ぷぅの研究活動

院長・夫律子(Dr.ぷぅ)は国際学会でも高く評価されており、国内外の学会・研究会からたくさんの講演依頼が届くほど。
こちらでは、Dr.ぷぅの学術論文や研究活動について発信しています。

【日本初】妊娠初期の患者全例に「妊娠高血圧腎症リスク判定」を実施

【日本初】妊娠初期の患者全例に「妊娠高血圧腎症リスク判定」を実施

2025年4月より、クリフムでは妊娠高血圧腎症(PE)スクリーニング検査によるリスク判定を開始しました。この取り組みは妊娠高血圧腎症の予防と啓発を目的としたもので、初期胎児ドック49,800円(税込)内に含まれている検査です。妊娠初期に来院する患者の「全例」に実施するようになったのは、クリフムが日本初となります。

【AJOGに掲載・症例報告】羊水検査は陰性、それでも原因は「体細胞モザイク」。右半球の過誤腫に限局したOFD1変異

【AJOGに掲載・症例報告】羊水検査は陰性、それでも原因は「体細胞モザイク」。右半球の過誤腫に限局したOFD1変異

このたび、当院(クリフム出生前診断クリニック、夫律子)を中心とするチームの症例報告が、産婦人科領域トップジャーナル「American Journal of Obstetrics & Gynecology(AJOG)」に掲載されました。「羊水の遺伝学的検査が陰性でも、脳の病変部だけにおこった遺伝子変異が原因となり得る」ことを裏づけた症例報告です。

水頭症はかならずしも水頭症でない!?

水頭症はかならずしも水頭症でない!?

妊婦健診で医師に「水頭症の疑いがあります」と告げられ、どうしたらいいのかわからずクリフムに相談に来られる人がいます。
日本では胎児の脳分野に明るい産婦人科医はそう多くなく、脳室が拡大しているから水頭症と言われているケースも少なくはありません。また意外なことに、脳外科や神経内科、放射線科を専門分野とする医師も、生まれた後の脳のことには詳しくても、胎児の脳に詳しい専門家はほとんどいないのです。
水頭症について、胎児の脳の診断を専門にしているDr.ぷぅが解説します。

【世界初・ AJOGに掲載】ダウン症候群の胎児脳マーカー「カモメサイン」と「菲薄化サブプレート」を発見

【世界初・ AJOGに掲載】ダウン症候群の胎児脳マーカー「カモメサイン」と「菲薄化サブプレート」を発見

このたび、クリフム出生前診断クリニックの院長・夫律子を中心とする国際研究チームによる新たな発見が、産婦人科領域で最も権威のある学術誌のひとつ「American Journal of Obstetrics & Gynecology(AJOG)」に掲載されました。
論文では、ダウン症候群の胎児脳に見られる2つの特徴的な形態学的マーカー「カモメサイン」と「菲薄化サブプレート」の存在を明らかにしています。これは世界で初めて科学的に確認された発見であり、AJOGでの発表からわずか数週間で、同誌の「Most Read Articles Top 10(最も読まれた論文トップ10)」に選出されるなど、大きな反響を呼んでいます。

1996-2016年の研究活動ログ

1996年
経腟超音波法による胎児脳観察を開始し、経腟超音波法による胎児脳内血流の詳細をイギリスのジャーナルに報告
1998年
3D超音波を胎児中枢神経系観察に応用し、脳内構造がさらに詳細かつ正確に判断できることを報告
国際学会で「胎児脳 Fetal Brain」セッションの座長・シンポジストとして活躍
2000年
Dr.Poohの超音波画像がWhite Journal(Ultrasound Obset Gynecol)の表紙を飾る

※右図 R. K. Pooh. New application of B-flow sono-angiography in perinatology. Ultrasound Obset Gynecol. 2000 Feb; 15(2): 163.

Dr.Poohの超音波画像がWhite Journal(Ultrasound Obset Gynecol)の表紙
2011年
ロサンゼルスでの第21回ISUOG世界産婦人科超音波学会でAlfred Kratochwil賞を受賞

Alfred Kratochwil先生はウイーンの素晴らしい先生で、3D超音波の研究を何十年もされて産婦人科領域での3D超音波を作り上げた先生です。現在クリフムにもあるGEのVOLUSON E10という超音波の3D超音波は非常に完成度の高い機器ですが、これはもともとKratochwil先生がKretzTechnikと共同研究を重ねて作り上げられた3D超音波があるからなのです。ISUOG世界超音波学会ではKratochwil先生の功績をたたえ、先生の名前にちなんだAwardができ、この賞をいただいたことは大変名誉なことなのです。
※参照サイト:isuog「2011 Congress Awards」

2011年 第21回 ISUOG世界産婦人科超音波学会でのAlfred Kratochwil賞 授賞式の様子
2012年
パリでの第8回IAPM国際周産期アカデミーで準会員から正会員受賞
2015年
スペインのマドリッドで開かれた第12回WCPM世界周産期医学会でLifetime achievement賞を受賞

※右上図 授賞式の様子,Roberto Romero教授より授与
※右下図 Lifetime Achievement Award, World Association of Perinatal Medicine(2015, Madrid)

                                           スペイン・マドリッドでの第12回WCPM世界周産期医学会 Lifetime Achievement賞 授賞式の様子 Lifetime Achievement Award, World Association of Perinatal Medicine(2015, Madrid)
2016年
アルバニアのティラナで開かれた第32回国際Fetus as a PatientでSir William Liley賞を受賞

Sir William Liley(12 March 1929 – 15 June 1983)ウイリアムライリー先生は胎児治療において非常に有名なニュージーランドの先生です。周産期医学界において2004年から1年に1人だけ、顕著な貢献が認められるドクターにSir William Liley賞とそのメダルが授与されます。なんとDr.ぷぅ(Dr.Pooh)は日本人で初めての受賞者なのです。その他、周産期関連の国際学会・国内学会においても胎児画像診断・胎児脳・胎児中枢神経系のフィールドでのアクティビティは非常に高く評価されています。

Sir William Liley賞メダル

Dr.ぷぅの著書一覧

fetal_neurology

Baby shower ちいさな命と向き合った出生前診断9つの物語

胎児の命と向き合ってきた9組の家族のストーリー。家族それぞれの幸せを描きながら、出生前診断のあり方を伝える著書。

夫 律子著 幻冬舎.2022
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Ian_Donald_School_Atras

Ian Donald School Atlas of Advanced Ultrasound in Obstetrics & Gynecology

Pooh RK, Kurjak A 著 Jaypee出版. 2015
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obstetrics_gynecology

Donald School Textbook of Powerpoint Presentation on Advanced Ultrasound in Obstetrics & Gynecology

T.wataganara, R. K. Pooh, A. Kurjak著 Jaypee出版.2015
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fetal_neurology

Fetal Neurology

胎児神経学の専門書
胎児脳情報から新生児の神経学までを網羅する待ち望まれた新刊著書。

Pooh RK, Kurjak A 著 Jaypee出版.2009
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full_color_atlas_3d_4d_ultarasound_image_diacrisis

フルカラーアトラス最新3D/4D胎児超音波画像診断

様々な機能を備えた3D/4D超音波機器から、より正確で客観的な胎児の情報を得ることができ、患者の納得のいく診断につながる。診断を最終目的とせず、診断することがスタートであるという著者ならではの、胎児哲学を交えわかりやすく解説する。

夫 律子著 メディカ出版.大阪.2004
>>詳細情報(医学書専門店メテオMBC)


an_atlas_of_fetal_central_nervous_system_disease

An Atlas of Fetal Central Nervous System Disease

“An Atlas of Fetal Central Nervous System Disease Diagnosis and Management”
(胎児中枢神経病アトラス,診断と治療)
Pooh RK, Maeda K, Pooh KH.

Parthenon CRC Press, London, New York, 200
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